TY - JOUR PY - 2005// TI - Abnormal spatial and non-spatial cueing effects in mild cognitive impairment and Alzheimer's disease JO - Neurocase A1 - Tales, Andrea A1 - Snowden, Robert J. A1 - Haworth, Judy A1 - Wilcock, Gordon K. SP - 85 EP - 92 VL - 11 IS - 1 N2 - Our aim was to further characterize the clinical concept of mild cognitive impairment (MCI). We examined visual attention-related processing in 12 patients with amnestic MCI, 16 healthy older adults and 16 patients with Alzheimer's disease (AD) by measuring performance on computer-based tests of attentional disengagement, alerting ability, and inhibition of return. Unlike the healthy older controls, the patients with AD and the patients with amnestic MCI exhibited a significant detriment in both the ability to disengage attention from an incorrectly cued location and the ability to use a visual cue to produce an alerting effect. The pattern of results displayed by the MCI group indicates that patients who only appear clinically to suffer from a deficit in memory also display a deficit in specific aspects of visual attention-related processing, which closely resemble the magnitude seen in AD.
Language: en
LA - en SN - 1355-4794 UR - http://dx.doi.org/10.1080/13554790490896983 ID - ref1 ER -