TY  - JOUR
PY  - 2005//
TI  - Optical imaging of neuronal populations during decision-making
JO  - Science
A1  - Briggman, K. L.
A1  - Abarbanel, H. D. I.
A1  - Kristan, W. B.
SP  - 896
EP  - 901
VL  - 307
IS  - 5711
N2  - We investigated decision-making in the leech nervous system by stimulating identical sensory inputs that sometimes elicit crawling and other times swimming. Neuronal populations were monitored with voltage-sensitive dyes after each stimulus. By quantifying the discrimination time of each neuron, we found single neurons that discriminate before the two behaviors are evident. We used principal component analysis and linear discriminant analysis to find populations of neurons that discriminated earlier than any single neuron. The analysis highlighted the neuron cell 208. Hyperpolarizing cell 208 during a stimulus biases the leech to swim; depolarizing it biases the leech to crawl or to delay swimming.<p /> <p>Language: en</p>
LA  - en
SN  - 0036-8075
UR  - http://dx.doi.org/10.1126/science.1103736
ID  - ref1
ER  -