TY  - JOUR
PY  - 2012//
TI  - Coaction of stress and serotonin transporter genotype in predicting aggression at the transition to adulthood
JO  - Journal of clinical child and adolescent psychology
A1  - Conway, Christopher C.
A1  - Keenan-Miller, Danielle
A1  - Hammen, Constance L.
A1  - Lind, Penelope A.
A1  - Najman, Jake M.
A1  - Brennan, Patricia A.
SP  - 53
EP  - 63
VL  - 41
IS  - 1
N2  - Despite consistent evidence that serotonin functioning affects stress reactivity and vulnerability to aggression, research on serotonin gene-stress interactions (G × E) in the development of aggression remains limited. The present study investigated variation in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-aggression association at the transition to adulthood. Multiple informants and multiple measures were used to assess aggression in a cohort of 381 Australian youth (61% female, 93% Caucasian) interviewed at ages 15 and 20. At age 20, semistructured interviews assessed acute and chronic stressors occurring in the past 12 months. Structural equation modeling analyses revealed a significant main effect of chronic stress, but not 5-HTTLPR or acute stress, on increases in aggression at age 20. Consistent with G × E hypotheses, 5-HTTLPR short allele carriers demonstrated greater increments in aggression following chronic stress relative to long allele homozygotes. The strength of chronic stress G × E did not vary according to sex. Variation at 5-HTTLPR appears to contribute to individual differences in aggressive reactions to chronic stress at the transition to adulthood.<p />  <p>Language: en</p>
LA  - en
SN  - 1537-4416
UR  - http://dx.doi.org/10.1080/15374416.2012.632351
ID  - ref1
ER  -