TY  - JOUR
PY  - 2012//
TI  - The Timing of Injury in Utero Causing Respiratory Inhibition after Crying
JO  - Pediatrics international
A1  - Minowa, Hideki
A1  - Bando, Yuka
A1  - Yasuhara, Hajime
A1  - Ebisu, Reiko
A1  - Ohgitani, Ayako
SP  - 370
EP  - 374
VL  - 54
IS  - 3
N2  - Objective:  To clarify the timing of injuries in utero that cause respiratory inhibition after crying (RIAC), we evaluated infants with cranial ultrasound abnormalities diagnosed during hospitalization. Methods:  We retrospectively examined the medical records of preterm infants who were treated in the neonatal intensive care unit at Nara Prefectural Hospital in Nara, Japan from January 2006 through December 2010. Inclusion criterion was gestational age less than 34 weeks. We evaluated the perinatal factors and cranial ultrasound abnormalities associating with RIAC, feeding hypoxemia, and prolonged apnea. We also evaluated the timing of appearance of cranial ultrasound abnormalities. Results:  One hundred twenty five infants were examined. Mean gestational age was 30.6 ± 2.4 weeks and mean birth weight was 1,465 ± 454 g. The numbers of infants who showed RIAC, feeding hypoxemia, and prolonged apnea were 44, 48, and 63, respectively. Among 91 infants who showed cranial ultrasound abnormalities, 67 had increased echogenicity in the ganglionic eminence (GE). There was a significant relationship between increased echogenicity and RIAC (P < 0.001). Of the infants who showed increased echogenicity in the GE, 19 had this finding during the course of hospitalization. In these 19 infants, however, gestational age of those with RIAC was less than 31 weeks. Conclusion:  We speculate that the timing of intrauterine injury resulting in RIAC in infants is less than 31 gestational weeks. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.<p />  <p>Language: en</p>
LA  - en
SN  - 1328-8067
UR  - http://dx.doi.org/10.1111/j.1442-200X.2012.03560.x
ID  - ref1
ER  -