TY  - JOUR
PY  - 2011//
TI  - Sub-therapeutic doses in the treatment of depression: the implications of starting low and going slow
JO  - Journal of Mind-Body Regulation
A1  - de Jong, Veronica
A1  - Raz, Amir
SP  - 73
EP  - 84
VL  - 1
IS  - 2
N2  - Psychiatrists who opt to treat depression with antidepressant medication typically "start low and go slow" - initially prescribing modest doses and then gradually increasing them. General practitioners, moreover, tend to prescribe low, even sub-therapeutic, maintenance doses of antidepressants. Indeed, some patients report clinical improvements even while taking extremely low-dose medication. Controversial meta-analytic findings suggest a negligible clinical benefit of antidepressants over placebos for the treatment of mild-to-moderate depression, although both interventions improve depression ratings compared to no-treatment. Do sub-therapeutic doses of antidepressants provide a treatment prospect for healthcare professionals who wish to use placebo-like treatments for depression? In this paper, we use results from psychiatrist interviews to explore the vagaries of sub-therapeutic doses and shed light on whether they have a place in the armamentarium of the modern clinician.<p /> 
LA  - 
SN  - 1925-1688
UR  - http://dx.doi.org/
ID  - ref1
ER  -