TY  - JOUR
PY  - 2012//
TI  - Schizophrenia and risk-taking: Impaired reward but preserved punishment processing
JO  - Schizophrenia Research
A1  - Cheng, Gordon L. F.
A1  - Tang, Joey C. Y.
A1  - Li, Frendi W. S.
A1  - Lau, Esther Y. Y.
A1  - Lee, Tatia M. C.
SP  - 122
EP  - 127
VL  - 136
IS  - 1-3
N2  - Risky decision-making is subserved by the frontostriatal system, which includes a network of interconnected brain regions known to be dysfunctional in patients with schizophrenia. This study aimed to investigate whether and to what extent patients with schizophrenia display a different pattern of risk-taking behavior relative to matched healthy controls. The Balloon Analogue Risk Task (BART) and the Risky-Gains Task were used as naturalistic measures of risk-taking behavior in 25 patients with schizophrenia and 25 controls. Results of the BART revealed that patients behaved more conservatively, and this in turn led to suboptimal risky decision-making. Consistently, patients behaved more conservatively in the Risky-Gains Task. Interestingly, however, they adjusted the pattern of risk-taking following a punished trial similar to controls. These findings indicate that patients have impaired reward but preserved punishment processing. This study complements previous studies on decision-making in schizophrenia and suggests specific rather than widespread abnormalities along the frontostriatal system in schizophrenia.<p />  <p>Language: en</p>
LA  - en
SN  - 0920-9964
UR  - http://dx.doi.org/10.1016/j.schres.2012.01.002
ID  - ref1
ER  -