TY  - JOUR
PY  - 2012//
TI  - Epidemiological features and risk factor analysis of children with acute lung injury
JO  - World journal of pediatrics
A1  - Li, Yan
A1  - Wang, Quan
A1  - Chen, Hui
A1  - Gao, Heng-Miao
A1  - Zhou, Tong
A1  - Qian, Su-Yun
SP  - 43
EP  - 46
VL  - 8
IS  - 1
N2  - BACKGROUND: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) represents a devastating complication observed in critical care medicine. The purpose of this study is to investigate the epidemiological aspects of ALI/ARDS in pediatric intensive care unit (PICU) and risk factors of mortality. METHODS: Patients with ALI/ARDS in PICU of Beijing Children's Hospital, a tertiary medical center from November 1, 2005 to October 31, 2006 were included in this prospective study. We identified the risk factors for underlying diseases and mortality during a 3-month followup using multivariate logistic regression analysis. RESULTS: In 562 critically ill patients admitted to PICU of Beijing Children's Hospital, there were 15 ALI-non ARDS patients and 29 ARDS patients, resulting in an incidence of 7.8% (44/562). The mortality rate of ARDS was 24.1% (7/29) and that of ALI/ARDS was 18.2% (8/44). At a 3-month follow-up, 12 patients died after being discharged from PICU and the total mortality rate was 45.5% (20/44). ALI/ARDS patients with pulmonary disease had better outcomes than those with extra-pulmonary involvements (P<0.05). Discharge against medical advice, low PaO(2)/FiO(2) during hospital stay and high PaCO2 on PICU admission were risk factors of mortality. CONCLUSIONS: ARDS has a high mortality rate in PICU, especially in those with extra-pulmonary diseases. In addition to aggressive medical management of comorbidity, lung protection and avoidance of discharge against medical advice will decrease the mortality.<p />  <p>Language: en</p>
LA  - en
SN  - 1708-8569
UR  - http://dx.doi.org/10.1007/s12519-012-0334-8
ID  - ref1
ER  -