TY  - JOUR
PY  - 2012//
TI  - Age at onset versus family history and clinical outcomes in 1,665 international bipolar-I disorder patients
JO  - World psychiatry
A1  - Baldessarini, Ross J.
A1  - Tondo, Leonardo
A1  - Vazquez, Gustavo H.
A1  - Undurraga, Juan
A1  - Bolzani, Lorenza
A1  - Yildiz, Aysegul
A1  - Khalsa, Hari-Mandir K.
A1  - Lai, Massimo
A1  - Lepri, Beatrice
A1  - Lolich, Maria
A1  - Maffei, Pier Mario
A1  - Salvatore, Paola
A1  - Faedda, Gianni L.
A1  - Vieta, Eduard
A1  - Mauricio, Tohen
SP  - 40
EP  - 46
VL  - 11
IS  - 1
N2  - Early onset in bipolar disorder (BPD) has been associated with greater familial risk and unfavorable clinical outcomes. We pooled data from seven international centers to analyze the relationships of family history and symptomatic as well as functional measures of adult morbidity to onset age, or onset in childhood (age <12), adolescence (12-18), or adulthood (19-55 years). In 1,665 adult, DSM-IV BPD-I patients, onset was 5% in childhood, 28% in adolescence, and 53% at peak ages 15-25. Adolescent and adult onset did not differ by symptomatic morbidity (episodes/year, percentage of months ill, co-morbidity, hospitalization, suicide attempts) or family history. Indications of favorable adult functional outcomes (employment, living independently, marriage and children, and a composite measure including education) ranked, by onset: adult > adolescent > child. Onset in childhood versus adolescence had more episodes/year and more psychiatric co-morbidity. Family history was most prevalent with childhood onset, similar over onset ages 12-40 years, and fell sharply thereafter. Multivariate modeling sustained the impression that family history and poor functional, but not symptomatic, outcomes were associated with younger, especially childhood onset. Early onset was more related to poor functional outcomes than greater symptomatic morbidity, with least favorable outcomes and greater family history with childhood onset.<p />  <p>Language: en</p>
LA  - en
SN  - 1723-8617
UR  - http://dx.doi.org/10.1016/j.wpsyc.2012.01.006
ID  - ref1
ER  -