TY  - JOUR
PY  - 2011//
TI  - Heritability of problem drinking and the genetic overlap with personality in a general population sample
JO  - Frontiers in genetics
A1  - de Moor, Marleen H. M.
A1  - Vink, Jacqueline M.
A1  - van Beek, Jenny H. D. A.
A1  - Geels, Lot M.
A1  - Bartels, Meike
A1  - de Geus, Eco J. C.
A1  - Willemsen, Gonneke
A1  - Boomsma, Dorret I.
SP  - 76
EP  - 76
VL  - 2
IS  - 
N2  - This study examined the heritability of problem drinking and investigated the phenotypic and genetic relationships between problem drinking and personality. In a sample of 5,870 twins and siblings and 4,420 additional family members from the Netherlands Twin Register. Data on problem drinking (assessed with the AUDIT and CAGE; 12 items) and personality [NEO Five-Factor Inventory (FFI); 60 items] were collected in 2009/2010 by surveys. Confirmatory factor analysis on the AUDIT and CAGE items showed that the items clustered on two separate but highly correlated (r = 0.74) underlying factors. A higher-order factor was extracted that reflected those aspects of problem drinking that are common to the AUDIT and CAGE, which showed a heritability of 40%. The correlations between problem drinking and the five dimensions of personality were small but significant, ranging from 0.06 for Extraversion to -0.12 for Conscientiousness. All personality dimensions (with broad-sense heritabilities between 32 and 55%, and some evidence for non-additive genetic influences) were genetically correlated with problem drinking. The genetic correlations were small to modest (between |0.12| and |0.41|). Future studies with longitudinal data and DNA polymorphisms are needed to determine the biological mechanisms that underlie the genetic link between problem drinking and personality.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-8021
UR  - http://dx.doi.org/10.3389/fgene.2011.00076
ID  - ref1
ER  -