TY  - JOUR
PY  - 1999//
TI  - Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt
JO  - European Neuropsychopharmacology
A1  - Träskman-Bendz, Lil
A1  - Ekman, Rolf
A1  - Westrin, A.
SP  - 205
EP  - 211
VL  - 9
IS  - 3
N2  - In order to receive a further understanding of stress-regulation in depressed suicide attempters, peptides that are supposed to be related to the stress system (the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system) were studied in plasma. When compared with healthy controls, cortisol was high (p<0.001) and corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) appeared to be low (p<0.001) in patients who had recently attempted suicide. Patients who had repeatedly attempted suicide had the lowest NPY. A correlation between NPY and cortisol (p<0.05) was found in suicidal patients with depression NOS, whereas beta-endorphins correlated with cortisol (p<0.01) in suicidal patients with major depressive disorder. A postdexamethasone decrease of NPY was noted in the controls but not in the patients. These results suggest stress system alterations in suicidal patients with mood disorders.<p /> <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/
ID  - ref1
ER  -