TY  - JOUR
PY  - 1999//
TI  - Responses of microglia and neural progenitors to mechanical brain injury
JO  - Neuroreport
A1  - Tzeng, S. F.
A1  - Wu, J. P.
SP  - 2287
EP  - 2292
VL  - 10
IS  - 11
N2  - Neural cells have distinct responses to CNS injury; however, neural progenitor response to CNS injury is not yet documented. Stab injury combined with injection of bromodeoxyuridine (BrdU), a thymidine analog, into adult rat cortex above the lateral ventricle for 10 min resulted in activated microglia/macrophage infiltration along with nuclear factor kappa B (NF kappa B)/p65 activation at the lesion site. Most NF kappa B/p65+ cells displayed a phagocytic morphology. Under these conditions, profound cell apoptosis took place in the injured corpus callosum, but not in the subventricular/ventricular zone (SVZ/VZ). The SVZ/VZ-derived neural progenitors in both injected and non-injected contralateral hemispheres showed strong BrdU immunostaining, indicating that SVZ/VZ-derived neural progenitors of both hemispheres may undergo DNA synthesis in response to unilateral brain injury.<p /> <p>Language: en</p>
LA  - en
SN  - 0959-4965
UR  - http://dx.doi.org/
ID  - ref1
ER  -