TY  - JOUR
PY  - 1999//
TI  - Fatal flecainide intoxication
JO  - Forensic science international
A1  - Romain, N.
A1  - Giroud, C.
A1  - Michaud, K.
A1  - Augsburger, M.
A1  - Mangin, Patrice
SP  - 115
EP  - 123
VL  - 106
IS  - 2
N2  - A fatal case attributed to flecainide acetate (Tambocor), a class Ic antiarrythmic drug, is presented. Flecainide was detected by GC/MS in gastric contents, blood and liver as well. The urine analysis revealed the presence of its dealkylated metabolite. Body fluids and tissue concentrations determined by GC/ECD were 7.7 mg/kg in femoral blood, 0.26 mg/kg in bile, 18 mg/kg in liver, 0.17 mg/kg in cerebrospinal fluid, 0.22 mg/kg in brain cortex and 28.9 mg/kg in urine. The total amount of flecainide in gastric contents was about 43 mg. Even taking into account the postmortem redistribution of flecainide, its blood level still remains in the toxic range.<p /> <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/
ID  - ref1
ER  -