TY  - JOUR
PY  - 2012//
TI  - A recent evaluation of the lethal potencies of ammodytoxins
JO  - Toxicon: Journal of the International Society on Toxinology
A1  - Prijatelj-Žnidaršič, Petra
A1  - Pungercar, Joze
SP  - 642
EP  - 643
VL  - 59
IS  - 6
N2  - Ammodytoxin A (AtxA) is the most toxic secreted phospholipase A(2) of the three isotoxins with presynaptic neurotoxicity, isolated from the venom of the nose-horned viper (Vipera ammodytes ammodytes), with an LD(50) of 21 μg/kg in mice. The toxic potencies of two other isoforms have been re-evaluated using highly purified recombinant proteins, with their intraperitoneal LD(50)s determined as 960 μg/kg for AtxB and 310 μg/kg for AtxC. AtxB and AtxC differ from AtxA in only three and two amino acid residues, respectively.<p />  <p>Language: en</p>
LA  - en
SN  - 0041-0101
UR  - http://dx.doi.org/10.1016/j.toxicon.2012.02.009
ID  - ref1
ER  -