TY  - JOUR
PY  - 1976//
TI  - An approach to the toxicology of combustion products of materials
JO  - Environmental health perspectives
A1  - Petajan, J. H.
SP  - 65
EP  - 73
VL  - 17
IS  - 
N2  - Physiological and behavioral (conditioned avoidance) responses of male Long-Evans rats were determined during exposure to combustion products produced on thermal degradation of three different polymeric materials. Arterial blood samples were obtained for determination of carboxyhemoglobin (COHb) and acid/base status. Material A produced a syndrome of carbon monoxide (CO)-induced anoxia, the severity of which was a function of the mass of material degraded. Material B produced grand mal seizures despite COHb levels of less than 10%. Material C produced metabolic acidosis and a mild degree of CO-induced anoxia. Loss of avoidance responses occurred at significantly lower COHb levels for materials B and C in comparison to CO alone. Using responses to COHb as a reference, it was possible to detect the presence of other toxicants present in combustion products. Compounds found in smoke in very low concentrations may have a high degree of biological activity and be responsible for impairment of survival responses. We have labeled these compounds "limiting" toxicants. They constitute a significant hazard, which is added to that of CO and anoxia.<p /> <p>Language: en</p>
LA  - en
SN  - 0091-6765
UR  - http://dx.doi.org/
ID  - ref1
ER  -