TY  - JOUR
PY  - 1976//
TI  - Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin
JO  - Journal of pharmaceutical sciences
A1  - Bhattacharya, S. K.
A1  - Reddy, P. K.
A1  - Ghosal, S.
A1  - Singh, A. K.
A1  - Sharma, P. V.
SP  - 1547
EP  - 1549
VL  - 65
IS  - 10
N2  - CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated. An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved. The results indicate that swertiamarin and mangiferin antagonize each other in vivo and thereby reverse their CNS effects.<p /> <p>Language: en</p>
LA  - en
SN  - 0022-3549
UR  - http://dx.doi.org/
ID  - ref1
ER  -