TY  - JOUR
PY  - 2003//
TI  - No association between non-violent suicidal behavior and the serotonin transporter promoter polymorphism
JO  - American journal of medical genetics. part B, neuropsychiatric genetics
A1  - Courtet, Philippe
A1  - Buresi, Catherine
A1  - Abbar, Mocrane
A1  - Baud, Patrick
A1  - Boulenger, Jean-Philippe
A1  - Castelnau, Didier
A1  - Mouthon, Dominique
A1  - Malafosse, Alain
SP  - 72
EP  - 76
VL  - 116B
IS  - 1
N2  - There is compelling evidence that suicidal behavior is associated with the dysfunction of the serotonin system. A functional polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was recently identified and the presence of the short allele was associated with lower gene expression, lower 5-HT uptake and violent suicidal behavior. Thus, we attempted to determine whether 5-HTTLPR is also involved in the susceptibility to non-violent suicidal behavior. We compared the genotype from 166 West European Caucasians who attempted suicide by a non-violent mean with 139 controls with no history of suicidal behavior from the same ethnic origin. The frequencies of the S allele and the SS genotype in the sample who attempted non-violent suicide were not statistically different to those in the controls. Thus, the genetically altered expression of the 5-HT transporter might be associated with more severe or violent suicidal behavior, but not with non-violent suicidal behavior.<p /> <p>Language: en</p>
LA  - en
SN  - 1552-4841
UR  - http://dx.doi.org/10.1002/ajmg.b.10756
ID  - ref1
ER  -