TY  - JOUR
PY  - 2003//
TI  - Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure
JO  - Journal of toxicology - clinical toxicology
A1  - Lin, Nan-Chieh
A1  - Lin, Ja-Liang
A1  - Lin-Tan, Dan-Tzu
A1  - Yu, Chun-Chen
SP  - 877
EP  - 881
VL  - 41
IS  - 6
N2  - The article presents a patient with severe paraquat poisoning from dermal exposure, who had chemical bums to more than 10% of his body surface area, serum paraquat level 0.13 microg/mL 60 hr after exposure, and severe hypoxemia (PaO2 41.6 mmHg). The patient was successfully treated with combined initial megadoses of cyclophosphamide (15 mg/kg/day, total 2 days) with repeated methylprednisolone pulse therapy (15 mg/kg/day, total 6 days) and continuous dexamethasone administration (5 mg every 8 hr), and recovered completely without sequelae 3 months later. This treatment deserves further investigation in future clinical trials.<p /> <p>Language: en</p>
LA  - en
SN  - 0731-3810
UR  - http://dx.doi.org/
ID  - ref1
ER  -