TY  - JOUR
PY  - 2012//
TI  - Childhood predictors of antipsychotic use among young people in Finland
JO  - Pharmacoepidemiology and drug safety
A1  - Gyllenberg, David
A1  - Sourander, Andre
A1  - Helenius, Hans
A1  - Sillanmaki, Lauri
A1  - Huttunen, Jukka
A1  - Piha, Jorma
A1  - Kumpulainen, Kirsti
A1  - Tamminen, Tuula
A1  - Moilanen, Irma
A1  - Almqvist, Fredrik
SP  - 964
EP  - 971
VL  - 21
IS  - 9
N2  - OBJECTIVE: Information on who uses antipsychotic medication is limited to cross-sectional data. The objective of this study was to study the patterns of psychopathology at age 8 years and antipsychotic use between the ages of 12 and 25 years. METHODS: A total of 5525 subjects from the Finnish Nationwide 1981 birth cohort were linked to the National Prescription Register and the Hospital Discharge Register between 1994 and 2005. Information about parent-reported and teacher-reported conduct, hyperkinetic and emotional symptoms, and self-reported depressive symptoms was gathered at age 8 years. Information about antipsychotic use and about psychiatric disorders treated in hospitals between the ages of 12 and 25 years was register based. Diagnostic classes of hospital treatment included non-affective psychoses, affective disorders, and other psychiatric disorders. RESULTS: The cumulative incidence of antipsychotic use by age 25 years was 2.8% among men (n = 69) and 2.1% among women (n = 55). In both sexes, living with other than two biological parents at age 8 years was associated with antipsychotic use, and three fourths of antipsychotic users had been treated for psychiatric disorders in a hospital. Among men, the most common hospital diagnosis was non-affective psychoses (44% of all antipsychotic users), and antipsychotic use was associated with childhood conduct problems. Among women, the most common hospital diagnosis was affective disorders (38% of all antipsychotic users), and antipsychotic use was associated with emotional problems and self-reported depressive symptoms in childhood. CONCLUSIONS: Antipsychotic use in adolescence and young adulthood is different among men versus women both with regard to hospital diagnoses and childhood psychiatric problems. Copyright © 2012 John Wiley & Sons, Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 1053-8569
UR  - http://dx.doi.org/10.1002/pds.3265
ID  - ref1
ER  -