TY  - JOUR
PY  - 2002//
TI  - Tolerance to the neurotoxic effects of methamphetamine in young rats
JO  - European journal of pharmacology
A1  - Riddle, Evan L.
A1  - Kokoshka, Jerry M.
A1  - Wilkins, Diana G.
A1  - Hanson, Glen R.
A1  - Fleckenstein, Annette E.
SP  - 181
EP  - 185
VL  - 435
IS  - 2-3
N2  - The present study examined whether exposure to methamphetamine during adolescence (as determined in post-natal day 40 rats) might alter its effects when used in young adulthood (as assessed in post-natal day 90 rats). Results confirm that high-dose methamphetamine administration (4x10 mg/kg/injection, s.c., 2-h intervals) decreases striatal dopamine uptake and transporter ligand binding in post-natal day 90 rats; effects that were blocked if animals received six biweekly methamphetamine pretreatments (15 mg/kg; s.c.) beginning at post-natal day 40. This neuroprotection was not likely due to pharmacokinetic tolerance, since brain methamphetamine concentrations did not differ 1 h after the high-dose methamphetamine regimen among treated rats regardless of pretreatment. The methamphetamine biweekly pretreatment attenuated the hyperthermia caused by the neurotoxic methamphetamine regimen; a phenomenon that may have contributed to the neuroprotection.<p /> <p>Language: en</p>
LA  - en
SN  - 0014-2999
UR  - http://dx.doi.org/
ID  - ref1
ER  -