TY  - JOUR
PY  - 2012//
TI  - Evaluation of a Novel Rapid Test System for the Detection of Specific IgE to Hymenoptera Venoms
JO  - Journal of allergy (Cairo)
A1  - Pfender, Nikolai
A1  - Lucassen, Ralf
A1  - Offermann, Nadine
A1  - Schulte-Pelkum, Johannes
A1  - Fooke, Margrit
A1  - Jakob, Thilo
SP  - 862023
EP  - 862023
VL  - 2012
IS  - 
N2  - Background. The Allergy Lateral Flow Assay (ALFA) is a novel rapid assay for the detection of sIgE to allergens. The objective of this study is the evaluation of ALFA for the detection of sIgE to bee venom (BV) and wasp venom (WV) in insect venom allergic patients. Methods. Specific IgE to BV and WV was analyzed by ALFA, ALLERG-O-LIQ, and ImmunoCAP in 80 insect venom allergic patients and 60 control sera. Sensitivity and specificity of ALFA and correlation of ALFA and ImmunoCAP results were calculated. Results. The sensitivity/specificity of ALFA to the diagnosis was 100%/83% for BV and 82%/97% for WV. For insect venom allergic patients, the Spearman correlation coefficient for ALFA versus ImmunoCAP was 0.79 for BV and 0.80 for WV. However, significant differences in the negative control groups were observed. Conclusion. ALFA represents a simple, robust, and reliable tool for the rapid detection of sIgE to insect venoms.<p />  <p>Language: en</p>
LA  - en
SN  - 1687-9783
UR  - http://dx.doi.org/10.1155/2012/862023
ID  - ref1
ER  -