TY - JOUR PY - 2012// TI - "Vitamin D - why does it matter?" - Defining Vitamin D deficiency and its prevalence JO - Scandinavian journal of clinical and laboratory investigation supplementum A1 - Bischoff-Ferrari, Heike A. SP - 3 EP - 6 VL - 243 IS - N2 - Abstract Vitamin D deficiency is prevalent in about 50 % of adults and limited data support a similar prevalence in children. This is of concern, as vitamin D deficiency is a risk factor for falls and fractures and several double-blind RCTs provide evidence that supplementation reduces the risk of fall and fractures among the senior population. Further, large epidemiologic studies consistently report that vitamin D deficiency confers an increased risk of mortality, cardiovascular disease and cancer, especially colo-rectal cancer. However, as large clinical trials for non-musculoskeletal endpoints are missing today, public health recommendations are based primarily on bone health to argue vitamin D repletion in the population.

Language: en

LA - en SN - 0085-591X UR - http://dx.doi.org/10.3109/00365513.2012.681938 ID - ref1 ER -