TY  - JOUR
PY  - 2012//
TI  - Mediational Relations between 12-step Attendance, Depression, and Substance Use in Patients with Comorbid Substance Dependence and Major Depression
JO  - Addiction
A1  - Worley, Matthew J.
A1  - Tate, Susan R.
A1  - Brown, Sandra A.
SP  - 1974
EP  - 1983
VL  - 107
IS  - 11
N2  - AIM: Among patients with substance dependence and comorbid major depressive disorder (MDD) receiving treatment in a controlled trial, we examined if group differences in depression were mediated by 12-step involvement, and if the effects of 12-Step involvement on future alcohol and drug use were mediated by reductions in depression. DESIGN: Controlled trial of Twelve-Step Facilitation (TSF) and Integrated Cognitive Behavioral Therapy (ICBT), delivered in outpatient groups for 6 months with adjunct pharmacotherapy. SETTING: Outpatient dual diagnosis clinic in Veteran's Affairs Healthcare Center. PARTICIPANTS: Veterans (N = 209) diagnosed with alcohol, stimulant, or marijuana dependence and substance-independent MDD. MEASUREMENTS: Twelve-step attendance and affiliation, depression severity, percent days drinking, and percent days using drugs assessed at baseline and Months 3, 6, and 9. FINDINGS: In multilevel analyses greater 12-step meeting attendance predicted lower depression and mediated the superior depression outcomes of the TSF group, explaining 24.3% of the group difference in depression. Independent of treatment group, lower depression severity predicted lower future alcohol use and mediated the effects of 12-step meetings, explaining 15.7% of their effects on future drinking. Controlled, lagged models indicated these effects were not confounded by current substance use, suggesting that depression had unique associations with 12-step meeting attendance and future drinking. CONCLUSIONS: For patients with substance dependence and MDD, attendance at 12-step meetings is associated with mental health benefits that extend beyond substance use, and reduced depression could be a key mechanism whereby 12-step meetings reduce future drinking in this population.<p />  <p>Language: en</p>
LA  - en
SN  - 0965-2140
UR  - http://dx.doi.org/10.1111/j.1360-0443.2012.03943.x
ID  - ref1
ER  -