TY  - JOUR
PY  - 2013//
TI  - The Relation Between Posttraumatic Stress Disorder and Mild Traumatic Brain Injury Acquired During Operations Enduring Freedom and Iraqi Freedom: A Diffusion Tensor Imaging Study
JO  - Journal of head trauma rehabilitation
A1  - Bazarian, Jeffrey J.
A1  - Donnelly, Kerry
A1  - Peterson, Derick R.
A1  - Warner, Gary C.
A1  - Zhu, Tong
A1  - Zhong, Jianhui
SP  - 1
EP  - 12
VL  - 28
IS  - 1
N2  - OBJECTIVE:: To understand the relations of mild traumatic brain injury (TBI), blast exposure, and brain white matter structure to severity of posttraumatic stress disorder (PTSD). DESIGN:: Nested cohort study using multivariate analyses. PARTICIPANTS:: Fifty-two OEF/OIF veterans who served in combat areas between 2001 and 2008 were studied approximately 4 years after the last tour of duty. MAIN MEASURES:: PTSD Checklist-Military; Combat Experiences Survey, interview questions concerning blast exposure and TBI symptoms; anatomical magnetic resonance imaging (MRI), and diffusion tensor imaging (DTI) scanning of the brain. RESULTS:: PTSD severity was associated with higher 1st percentile values of mean diffusivity on DTI (regression coefficient [r] = 4.2, P = .039), abnormal MRI (r = 13.3, P = .046), and the severity of exposure to combat events (r = 5.4, P = .007). Mild TBI was not significantly associated with PTSD severity. Blast exposure was associated with lower 1st percentile values of fractional anisotropy on DTI (odds ratio [OR] = 0.38 per SD; 95% confidence interval [CI], 0.15-0.92), normal MRI (OR = 0.00, 95% likelihood ratio test CI, 0.00-0.09), and the severity of exposure to traumatic events (OR = 3.64 per SD; 95% CI, 1.40-9.43). CONCLUSIONS:: PTSD severity is related to both the severity of combat stress and underlying structural brain changes on MRI and DTI but not to a clinical diagnosis of mild TBI. The observed relation between blast exposure and abnormal DTI suggests that subclinical TBI may play a role in the genesis of PTSD in a combat environment.<p />  <p>Language: en</p>
LA  - en
SN  - 0885-9701
UR  - http://dx.doi.org/10.1097/HTR.0b013e318256d3d3
ID  - ref1
ER  -