TY  - JOUR
PY  - 2012//
TI  - Development of animal model for studying deep second-degree thermal burns
JO  - Journal of biomedicine and biotechnology
A1  - Tavares Pereira, Danielle Dos Santos
A1  - Lima-Ribeiro, Maria Helena Madruga
A1  - de Pontes-Filho, Nicodemos Teles
A1  - Carneiro-Leão, Ana Maria Dos Anjos
A1  - Correia, Maria Tereza Dos Santos
SP  - 460841
EP  - 460841
VL  - 2012
IS  - online
N2  - Thermal lesions were produced in 12 male Wistar rats, positioning a massive aluminum bar 10 mm in diameter (51 g), preheated to 99°C ± 2°C/10 min. on the back of each animal for 15 sec. After 7, 14, 21, and 28 days, animals were euthanized. The edema intensity was mild, with no bubble and formation of a thick and dry crust from the 3rd day. The percentage of tissue shrinkage at 28 days was 66.67 ± 1.66%. There was no sign of infection, bleeding, or secretion. Within 28 days reepithelialization was incomplete, with fibroblastic proliferation and moderate fibrosis and presence of modeled dense collagen fibers. It is concluded that the model established is applicable in obtaining deep second-degree thermal burns in order to evaluate the healing action of therapeutic agents of topical use.<p />  <p>Language: en</p>
LA  - en
SN  - 1110-7243
UR  - http://dx.doi.org/10.1155/2012/460841
ID  - ref1
ER  -