TY  - JOUR
PY  - 1990//
TI  - Association between family history of affective disorder and the depressive syndrome of Alzheimer's disease
JO  - American journal of psychiatry
A1  - Pearlson, Godfrey D.
A1  - Ross, C. A.
A1  - Lohr, W. D.
A1  - Rovner, B. W.
A1  - Chase, G. A.
A1  - Folstein, M. F.
SP  - 452
EP  - 456
VL  - 147
IS  - 4
N2  - For each of 41 index patients with probable Alzheimer's disease and a first episode of major depression and 71 nondepressed Alzheimer's disease patients, two first-degree relatives were interviewed by a rater blind to presence or absence of depression in the proband. The depressed patients had significantly more first- and second-degree relatives with depression than did control subjects. The lifetime risk for major depression, adjusted for differences in age distribution, was significantly greater in first-degree relatives of index patients, suggesting that depression in Alzheimer's disease is genetically related to primary affective disorder. Alzheimer's disease may be useful for studying aspects of depressive pathophysiology.<p /> <p>Language: en</p>
LA  - en
SN  - 0002-953X
UR  - http://dx.doi.org/
ID  - ref1
ER  -