TY  - JOUR
PY  - 2007//
TI  - Brain substrates of craving to alcohol cues in subjects with alcohol use disorder
JO  - Alcohol and alcoholism
A1  - Park, Mi-Sook
A1  - Sohn, Jin-Hun
A1  - Suk, Ji-A
A1  - Kim, Sook-Hee
A1  - Sohn, Sunju
A1  - Sparacio, Richard
SP  - 417
EP  - 422
VL  - 42
IS  - 5
N2  - AIMS: This study's purpose was to identify the neural substrates and mechanisms responsible for craving among subjects with alcohol use disorders (AUDs) using functional magnetic resonance imaging (fMRI). METHODS: Alcohol abusers with AUD (n = 9) and demographically similar non-abusers (n = 9) participated in this study. After given 5 cc of alcohol, subjects were exposed to different types of stimuli [i.e. alcohol, non-alcoholic beverage, and visual control pictures and one rest (cross-hair)]. Craving levels were rated through self-report on a Likert scale immediately after the presentation of visual cues. RESULTS: Brain activations in the fusiform gyri, temporal gyri, parahippocampal gyrus, uncus, frontal gyri, and precuneus were correlated with the level of craving among subjects with AUD in response to alcohol cues. CONCLUSIONS: In conclusion, specific brain regions were identified that are associated with craving among subjects with AUD.<p /> <p>Language: en</p>
LA  - en
SN  - 0735-0414
UR  - http://dx.doi.org/10.1093/alcalc/agl117
ID  - ref1
ER  -