TY  - JOUR
PY  - 2002//
TI  - Role of genotype in the cycle of violence in maltreated children
JO  - Science
A1  - Caspi, Avshalom
A1  - McClay, Joseph
A1  - Moffitt, Terrie E.
A1  - Mill, Jonathan
A1  - Martin, Judy
A1  - Craig, Ian W.
A1  - Taylor, Alan
A1  - Poulton, Richie
SP  - 851
EP  - 854
VL  - 297
IS  - 5582
N2  - We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A (MAOA) was found to moderate the effect of maltreatment. Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems. These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults.<p /> <p>Language: en</p> 
LA  - en
SN  - 0036-8075
UR  - http://dx.doi.org/10.1126/science.1072290
ID  - ref1
ER  -