TY  - JOUR
PY  - 2009//
TI  - Cortical thinning in persons at increased familial risk for major depression
JO  - Proceedings of the National Academy of Sciences of the United States of America
A1  - Peterson, Bradley S.
A1  - Warner, Virginia
A1  - Bansal, Ravi
A1  - Zhu, Hongtu
A1  - Hao, Xuejun
A1  - Liu, Juhua
A1  - Durkin, Kathleen
A1  - Adams, Phillip B.
A1  - Wickramaratne, Priya
A1  - Weissman, Myrna M.
SP  - 6273
EP  - 6278
VL  - 106
IS  - 15
N2  - The brain disturbances that place a person at risk for developing depression are unknown. We imaged the brains of 131 individuals, ages 6 to 54 years, who were biological descendants (children or grandchildren) of individuals identified as having either moderate to severe, recurrent, and functionally debilitating depression or as having no lifetime history of depression. We compared cortical thickness across high- and low-risk groups, detecting large expanses of cortical thinning across the lateral surface of the right cerebral hemisphere in persons at high risk. Thinning correlated with measures of current symptom severity, inattention, and visual memory for social and emotional stimuli. Mediator analyses indicated that cortical thickness mediated the associations of familial risk with inattention, visual memory, and clinical symptoms. These findings suggest that cortical thinning in the right hemisphere produces disturbances in arousal, attention, and memory for social stimuli, which in turn may increase the risk of developing depressive illness.<p /> <p>Language: en</p> 
LA  - en
SN  - 0027-8424
UR  - http://dx.doi.org/10.1073/pnas.0805311106
ID  - ref1
ER  -