TY  - JOUR
PY  - 2012//
TI  - Acute ibuprofen intoxication: report on a case and review of the literature
JO  - American journal of forensic medicine and pathology
A1  - Lodise, Maria
A1  - De Giorgio, Fabio
A1  - Rossi, Riccardo
A1  - d'Aloja, Ernesto
A1  - Fucci, Nadia
SP  - 242
EP  - 246
VL  - 33
IS  - 3
N2  - ABSTRACT: A fatality following the ingestion of ibuprofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug widely prescribed as an analgesic, anti-inflammatory, and antipyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. We report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the emergency department by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt.Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidone, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the emergency department, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography/mass spectrometry technique. The estimated ibuprofen concentration in the plasma was 600 μg/mL; gastric content was 200 μg/mL for this compound. Our report describes results of the forensic investigation and discuss the review of the literature.<p />  <p>Language: en</p>
LA  - en
SN  - 0195-7910
UR  - http://dx.doi.org/10.1097/PAF.0b013e318253d6ff
ID  - ref1
ER  -