TY  - JOUR
PY  - 2012//
TI  - Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide
JO  - Neuropsychobiology
A1  - Chojnicka, Izabela
A1  - Strawa, Katarzyna
A1  - Fudalej, Sylwia
A1  - Fudalej, Marcin
A1  - Pawlak, Aleksandra
A1  - Kostrzewa, Grażyna
A1  - Wojnar, Marcin
A1  - Krajewski, Paweł
A1  - Płoski, Rafał
SP  - 134
EP  - 140
VL  - 66
IS  - 2
N2  - Background: We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide. Methodology: We used a case-control two-stage approach based on a discovery cohort (557 cases and ∼550 controls) and replication cohort (159 cases and 186 controls). The suicides were ascertained as consecutive cases autopsied at the Department of Forensic Medicine, Medical University of Warsaw, Poland. Results: In the discovery cohort we found an association between suicide and the CC genotype in the rs4307059 polymorphism (OR 1.64, p = 0.012). The trend for an overrepresentation of the CC homozygotes among suicides was replicated in the second cohort (OR 1.97, p = 0.056). Analysis in the pooled cohorts showed that rs4307059 CC was associated with completed suicide (OR 1.71, p = 0.002) also after Bonferroni correction (p(cor.) = 0.024). In an exploratory search for genotype-phenotype correlation we found that males with the rs4307059 CC genotype committed suicide earlier than those with CT/TT genotypes (p = 0.049). Conclusions: The CC genotype of rs4307059 located in the region between CDH9 and CDH10 is associated with completed suicide in a Polish cohort.<p />  <p>Language: en</p>
LA  - en
SN  - 0302-282X
UR  - http://dx.doi.org/10.1159/000339559
ID  - ref1
ER  -