TY - JOUR PY - 2012// TI - Glia and methylmercury neurotoxicity JO - Journal of toxicology and environmental health - Part A A1 - Ni, Mingwei A1 - Li, Xin A1 - Rocha, João B. T. A1 - Farina, Marcelo A1 - Aschner, Michael SP - 1091 EP - 1101 VL - 75 IS - 16-17 N2 - Methylmercury (MeHg) is a global environmental pollutant with significant adverse effects on human health. As the major target of MeHg, the central nervous system (CNS) exhibits the most recognizable poisoning symptoms. The role of the two major nonneuronal cell types, astrocytes and microglia, in response to MeHg exposure was recently compared. These two cell types share several common features in MeHg toxicity, but interestingly, these cells types also exhibit distinct response kinetics, indicating a cell-specific role in mediating MeHg-induced neurotoxicity. The aim of this study was to review the most recent literature and summarize key features of glial responses to this organometal.
Language: en
LA - en SN - 1528-7394 UR - http://dx.doi.org/10.1080/15287394.2012.697840 ID - ref1 ER -