TY  - JOUR
PY  - 2012//
TI  - Possible genetic association between vasopressin receptor 1B and child aggression
JO  - Psychiatry research
A1  - Zai, Clement C.
A1  - Muir, Katherine E.
A1  - Nowrouzi, Behdin
A1  - Shaikh, Sajid A.
A1  - Choi, Esther
A1  - Berall, Laura
A1  - Trépanier, Marc-Olivier
A1  - Beitchman, Joseph H.
A1  - Kennedy, James L.
SP  - 784
EP  - 788
VL  - 200
IS  - 2-3
N2  - Background: Studies on animal models have implicated arginine vasopressin signalling pathway in aggressive behaviour. The role of arginine vasopressin in childhood onset aggression is unclear. Methods: We investigated 11 single-nucleotide polymorphisms in the genes coding for arginine vasopressin and its receptors in our sample of 177 aggressive child cases paired with adult controls matched for sex and ethnicity. Results: We found the non-synonymous polymorphism AVPR1B_rs35369693 to be associated with child aggression in our sample (P=0.007). We also found two-marker haplotype window containing AVPR1B_rs35369693 and AVPR1B_rs28676508 to be associated (P=0.003). The haplotype findings survived multiple-testing adjusted significance threshold of 0.0063. Conclusions: This is the first report of a genetic association between vasopressin receptor 1B and child aggression. Replication in independent samples are required to confirm these findings.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2012.07.031
ID  - ref1
ER  -