TY  - JOUR
PY  - 2006//
TI  - Enriched environment treatment counteracts enhanced addictive and depressive-like behavior induced by prenatal chronic stress
JO  - Brain research
A1  - Yang, Jianli
A1  - Li, Weihui
A1  - Liu, Xiaohua
A1  - Li, Zexuan
A1  - Li, Hongying
A1  - Yang, Guifu
A1  - Xu, Lin
A1  - Li, Lingjiang
SP  - 132
EP  - 137
VL  - 1125
IS  - 1
N2  - Prenatal stress can cause many long-term behavior changes in offspring, but whether prenatal stress can alter addictive behavior in offspring and postnatal enriched environment treatment (EE) can restore these changes are unknown. We reported here that prenatal chronic stress (10 unpredictable, 1 s, 0.8 mA foot-shocks per day during gestational days 13-19) enhanced morphine-induced (10 mg/kg, s.c., per day, 6 consecutive days) place preference. Moreover, prenatal chronic stress caused higher depressive-like behavior in forced swimming test in adult offspring. However, enriched environment housing treatment on postnatal days 22-52 counteracted both the abnormal behaviors alterations. This work observed a phenomenon that might contribute to the understanding of clinically important interactions among addiction, prenatal stress and enriched environment treatment. Postnatal enriched environment treatment might be an important therapeutic intervention in preventing the prenatal stress-induced addictive disorders.<p /> <p>Language: en</p>
LA  - en
SN  - 0006-8993
UR  - http://dx.doi.org/10.1016/j.brainres.2006.10.028
ID  - ref1
ER  -