TY  - JOUR
PY  - 2007//
TI  - The association between recipient alcohol dependency and long-term graft and recipient survival
JO  - Nephrology, dialysis, transplantation
A1  - Gueye, Abdou S.
A1  - Chelamcharla, Madhukar
A1  - Baird, Bradley C.
A1  - Nguyen, Cuong
A1  - Tang, Hongying
A1  - Barenbaum, Anna L.
A1  - Koford, James K.
A1  - Shihab, Fuad
A1  - Goldfarb-Rumyantzev, Alexander S.
SP  - 891
EP  - 898
VL  - 22
IS  - 3
N2  - BACKGROUND: The causative role of alcohol consumption in renal disease is controversial, and its effect on renal graft and recipient survival has not been previously studied. METHODS: We analysed the association between pre-transplant [at the time of end-stage renal disease (ESRD) onset] alcohol dependency and renal graft and recipient survival. The United States Renal Data System (USRDS) records of kidney transplant recipients 18 years or older transplanted between 1 January 1995 and 31 December 2002 were examined. We used Kaplan-Meier analysis and Cox regression models adjusted for covariates to analyse the association between pre-transplant alcohol dependency and graft and recipient survival. RESULTS: In an entire study cohort of 60 523, we identified 425 patients with a history of alcohol dependency. Using Cox models, alcohol dependency was found to be associated with increased risk of death-censored graft failure [hazard ratio (HR) 1.38, P < 0.05] and increased risk of transplant recipient death (HR 1.56, P < 0.001). Subgroup analysis demonstrated an association of alcohol-dependency with recipient survival and death-censored graft survival in males (but not in females), and in both white and non-white racial subgroups. CONCLUSIONS: We concluded that alcohol dependency at the time of ESRD onset is a risk factor for renal graft failure and recipient death.<p /> <p>Language: en</p>
LA  - en
SN  - 0931-0509
UR  - http://dx.doi.org/10.1093/ndt/gfl689
ID  - ref1
ER  -