TY  - JOUR
PY  - 2006//
TI  - Compliance with poison center fomepizole recommendations is suboptimal in cases of toxic alcohol poisoning
JO  - American journal of therapeutics
A1  - Mycyk, Mark B.
A1  - DesLauriers, Carol
A1  - Metz, Jessica
A1  - Wills, Brandon
A1  - Mazor, Suzan S.
SP  - 485
EP  - 489
VL  - 13
IS  - 6
N2  - We sought to examine hospital compliance with poison center antidotal alcohol dehydrogenase inhibition recommendations in cases of ethylene glycol (EG) and methanol (ME) ingestion. A 2-year analysis of all potential EG and ME ingestion cases reported to a regional poison center was conducted. Excluded from analysis were exposures without an ingestion, without a confirmatory EG or ME serum assay, or without complete medical charting. During the study period, 579 EG or ME exposures were reported to the poison center: 133 cases met study eligibility as an ingestion. Of the 133 cases, 102 (77%) had complete data and were included in the analysis. Immediate alcohol dehydrogenase inhibition was recommended by the poison center in 79 of the 102 cases. Fomepizole was recommended in 61/79 (77%); ethanol was recommended as an alternative therapeutic choice in 32/61 (52%) of these cases if fomepizole was not immediately available. Ethanol alone was recommended in 18/79 (23%). Fomepizole was eventually administered in 39/61 (64%) cases where recommended. The mean time to antidote administration was 3 times longer in cases where a choice in antidote was given [57 min (95% confidence interval, 43-70) vs. 146 min (95% confidence interval, 93-200)]. Despite its ease of administration, fomepizole is used less frequently than recommended by poison center staff. Delays to antidote administration occurred more commonly in cases where the poison center gave a choice in antidotal therapy.<p /> <p>Language: en</p>
LA  - en
SN  - 1075-2765
UR  - http://dx.doi.org/10.1097/01.mjt.0000208878.53856.a5
ID  - ref1
ER  -