TY  - JOUR
PY  - 2013//
TI  - Fatal doxepin intoxication - Suicide or slow gradual intoxication?
JO  - Forensic science international
A1  - Neukamm, M. A.
A1  - Vogt, S.
A1  - Hermanns-Clausen, M.
A1  - Naue, J.
A1  - Thierauf, A.
A1  - Auwärter, V.
SP  - 82
EP  - 84
VL  - 227
IS  - 1-3
N2  - The differentiation of intoxication courses is one of the most difficult challenges for forensic pathologists and toxicologists. The case of a 52-year-old female inpatient of a psychiatric clinic with multiple medications who died from doxepin intoxication is reported. Concentrations of doxepin metabolites and isomers, pharmacokinetic modelling and genotyping of the doxepin-metabolizing cytochrome P450 (CYP) enzymes led to the following conclusion: the lethal doxepin concentration of 2100ng/mL was more likely to have been reached due to drug interactions and genetic peculiarities leading to a reduction of the metabolic capacity and not by an acute (suicidal) overdose.<p />  <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/10.1016/j.forsciint.2012.08.050
ID  - ref1
ER  -