TY  - JOUR
PY  - 2013//
TI  - Multiple organ dysfunction: A delayed envenomation syndrome caused by tentacle extract from the jellyfish Cyanea capillata
JO  - Toxicon: Journal of the International Society on Toxinology
A1  - Wang, Beilei
A1  - Zhang, Lin
A1  - Zheng, Jiemin
A1  - Wang, Qianqian
A1  - Wang, Tao
A1  - Lu, Jia
A1  - Wen, Xiaojuan
A1  - Zhang, Bin
A1  - Liu, Guoyan
A1  - Zhang, Weigang
A1  - Xiao, Liang
A1  - Zhang, Liming
SP  - 54
EP  - 61
VL  - 61
IS  - 
N2  - The delayed jellyfish envenomation syndrome (DJES) with serious multiple organ dysfunction or systemic damages, generally developed 2 hours after jellyfish stings, deserves special attentions for it is very meaningful to the clinical interventions. To set up a DJES model as well as to obtain more details about its process, an integrative approach, including clinical chemistry, pathology and immunohistochemistry, was conducted to simultaneously monitor the effects of tentacle extract (TE) from the jellyfish Cyanea capillata on the vital target organs (heart, lung, liver and kidney). Our results showed that the TE from C. capillata could induce diverse toxic effects on these organs, among which the liver and kidney injuries seemed to be more serious than cardiopulmonary injuries and might be the leading causes of death in rats with DJES. In summary, we have established a DJES model with multiple organ dysfunction, which could facilitate the research on its underlying mechanism as well as the development of specific prevention or therapy strategies against jellyfish envenomation. The application of this model suggested that the possible mechanism of DJES might be attributed to the synergy of cytotoxicity, vasoconstriction effect and other specific target organ toxicities of jellyfish venom.<p />  <p>Language: en</p>
LA  - en
SN  - 0041-0101
UR  - http://dx.doi.org/10.1016/j.toxicon.2012.11.003
ID  - ref1
ER  -