TY  - JOUR
PY  - 2012//
TI  - Acute indoramin poisoning: a review of 55 cases reported to the Paris poison centre from 1986 t o 2010
JO  - Therapie
A1  - Villa, Antoine F.
A1  - Tran Hong, Huan
A1  - Min Lee, Hwee
A1  - Chataigner, Dominique
A1  - Garnier, Robert
SP  - 523
EP  - 527
VL  - 67
IS  - 6
N2  - Authors report a retrospective study of all cases of indoramin-only poisoning notified to the Paris poison Centre from 1986 to 2010. Fifty five cases of indoramin self-poisoning were included: 40 adults and 15 children. The mean supposed ingested dose was about 701 mg±464 mg. ECG showed a prolonged QTc interval (equal to or greater than 0.50 s) in 30% of patients. The lowest observed dose for prolonged QTc was 625 mg. This series includes two cases of seizures occurring around two hours after ingestion of 900 and 2 250 mg of indoramin. A review of the literature showed cardiac disorders, with a delayed mechanism of action up until 18 hours after ingestion. Therefore, rapid medical resuscitation and prolonged cardiac monitoring for at least 24 hours after ingestion of 625 mg are recommended.<p />  <p>Language: en</p>
LA  - en
SN  - 0040-5957
UR  - http://dx.doi.org/10.2515/therapie/2012075
ID  - ref1
ER  -