TY  - JOUR
PY  - 2004//
TI  - Survival after a lethal dose of arsenic trioxide
JO  - Journal of toxicology - clinical toxicology
A1  - Vantroyen, Barbara
A1  - Heilier, J. F.
A1  - Meulemans, Agnes
A1  - Michels, Arnold
A1  - Buchet, J. P.
A1  - Vanderschueren, Steven
A1  - Haufroid, V.
A1  - Sabbe, Marc
SP  - 889
EP  - 895
VL  - 42
IS  - 6
N2  - A case of a 27-year-old woman who ingested 9000 mg arsenic trioxide (As2O3) is reported. Classical symptoms of an acute arsenicum (As) poisoning such as gastrointestinal cramps, vomiting, diarrhea, ECG changes and disturbed liver function tests were observed. The absorption of the ingested As was minimalized by a continuous gastric irrigation with highly concentrated NaHCO3 and intestinal cleansing with NaHCO3 and polyethyleneglycol was performed. Forced diuresis, BAL (2,3-dimercaptopropanol) and DMSA (meso-2,3-dimercaptosuccinic acid) were started and therapy to enhance the formation of methylated As derivatives, which are potentially less toxic and which can be excreted more easily, was then administered. The patient survived this massive dose of ingested inorganic As with only polyneuropathy one year later.<p /> <p>Language: en</p>
LA  - en
SN  - 0731-3810
UR  - http://dx.doi.org/
ID  - ref1
ER  -