TY  - JOUR
PY  - 2013//
TI  - Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence
JO  - Journal of Adolescent Health
A1  - Heinzerling, Keith G.
A1  - Gadzhyan, Janette
A1  - van Oudheusden, Henry
A1  - Rodriguez, Felipe
A1  - McCracken, James
A1  - Shoptaw, Steven
SP  - 502
EP  - 505
VL  - 52
IS  - 4
N2  - PURPOSE: To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents. METHODS: Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling. RESULTS: Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = .043) and males (p = .005) respectively. CONCLUSIONS: Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.<p />  <p>Language: en</p>
LA  - en
SN  - 1054-139X
UR  - http://dx.doi.org/10.1016/j.jadohealth.2012.10.275
ID  - ref1
ER  -