TY  - JOUR
PY  - 2004//
TI  - Identification of high-risk patients after minor craniocerebral trauma. Measurement of nerve tissue protein S 100
JO  - Unfallchirurg
A1  - Biberthaler, P.
A1  - Mussack, T.
A1  - Kanz, K-G
A1  - Linsenmaier, U.
A1  - Pfeifer, K-j
A1  - Mutschler, W.
A1  - Jochum, M.
SP  - 197
EP  - 202
VL  - 107
IS  - 3
N2  - The indication for an initial cranial computed tomography (CCT) in minor head trauma (MHT) patients remains the subject of discussion. The aim of this study was to investigate whether a newly developed, rapid test system (ELECSYS S100, Roche Diagnostics) might allow a diagnostically valid, reproducible measurement of S 100 in MHT patients. Blood samples were drawn from 75 MHT patients, a CCT scan was performed, and those with a post-traumatic intracranial lesion counted as CCT+. Results were compared to a healthy control group (n=17). Of the 75 patients included in the study, 14 were stratified as CCT+. The systemic concentration of S 100 in these CCT+ patients was significantly increased (0.31 microg/l) compared to the healthy control group (0.04 microg/l) as well as to the CCT-negative patients (0.08 microg/l). The ELECSYS S100 system allows a rapid, valid, and reproducible assessment of S 100B in patient serum and this concentration is significantly elevated in patients suffering from intracranial lesions as shown by initial CCT scan. Hence, this study is the basis for a multicenter trial currently underway to confirm the results of our pilot study.<p /> <p>Language: de</p>
LA  - de
SN  - 0177-5537
UR  - http://dx.doi.org/10.1007/s00113-004-0730-1
ID  - ref1
ER  -