TY  - JOUR
PY  - 2013//
TI  - Serial monitoring of CO(2) reactivity following sport concussion using hypocapnia and hypercapnia
JO  - Brain injury
A1  - Len, Trevor K.
A1  - Neary, J. Patrick
A1  - Asmundson, Gordon J. G.
A1  - Candow, Darren G.
A1  - Goodman, David G.
A1  - Bjornson, Bruce
A1  - Bhambhani, Yagesh N.
SP  - 346
EP  - 353
VL  - 27
IS  - 3
N2  - Primary objective: This study examined the effects of mild traumatic brain injury (mTBI) on cerebrovascular reactivity (CVR). Research design: A repeated measures design was used to examine serial changes in CVR. Methods and procedures: Twenty subjects who recently suffered a mTBI were subjected to a respiratory challenge consisting of repeated 20 s breath-holds (BH) and hyperventilations (HV). Testing occurred on days 2 (D2), 4 (D4) and 8 (D8) post-injury as well as a baseline (BASE) assessment (after return-to-play). Transcranial Doppler was used to assess mean cerebral blood velocity (vMCA) and expired gas analysis provided end-tidal carbon dioxide (PETCO(2)) levels. Results: There was no significant difference in resting vMCA across all testing days for mTBI. No significant differences in PETCO(2) were found throughout the testing protocol. A significant effect (p < 0.001) of testing day on vMCA was found during BH and HV challenges for mTBI. Post-hoc analysis revealed significant differences (p < 0.05) in vMCA between D2 and the other testing days. Conclusions: These data suggest that, following mTBI: (1) CVR is not impaired at rest; (2) CVR is impaired in response to respiratory stress; and (3) the impairment may be resolved as early as 4 days post-injury.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-9052
UR  - http://dx.doi.org/10.3109/02699052.2012.743185
ID  - ref1
ER  -