TY - JOUR PY - 1971// TI - Irreversible effects on visible light on the retina: role of vitamin A JO - Science A1 - Noell, W. K. A1 - Albrecht, R. SP - 76 EP - 79 VL - 172 IS - 3978 N2 - Diffuse retinal irradiation by visible light produces in the rat the death of visual cells and pigment epithelium. Typically, cage illumination of 1500 lux from fluorescent light through a green filter leads to severe damage when continued for 40 hours. Vitamin A deficiency protects against this damage but experiments show that retinol released by light from rhodopsin is probably not the toxic agent. Protection against light damage depends on a long-range state of cell adaptation to light itself. The normal diurnal cycle of light and dark seems to be the essential factor in controlling visual cell viability and susceptibility.

Language: en

LA - en SN - 0036-8075 UR - http://dx.doi.org/ ID - ref1 ER -