TY  - JOUR
PY  - 2014//
TI  - MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors
JO  - Biological psychiatry
A1  - Haberstick, Brett C.
A1  - Lessem, Jeffrey M.
A1  - Hewitt, John K.
A1  - Smolen, Andrew
A1  - Hopfer, Christian Jean
A1  - Halpern, Carolyn T.
A1  - Killeya-Jones, Ley A.
A1  - Boardman, Jason D.
A1  - Tabor, Joyce
A1  - Siegler, Ilene C.
A1  - Williams, Redford B.
A1  - Mullan Harris, Kathleen
SP  - 25
EP  - 30
VL  - 75
IS  - 1
N2  - BACKGROUND: Maltreatment by an adult or caregiver during childhood is a prevalent and important predictor of antisocial behaviors in adulthood. A functional promoter polymorphism in the monoamine oxidase A (MAOA) gene has been implicated as a moderating factor in the relationship between childhood maltreatment and antisocial behaviors. Although there have been numerous attempts at replicating this observation, results remain inconclusive. METHODS: We examined this gene-environment interaction hypothesis in a sample of 3356 white and 960 black men (aged 24-34) participating in the National Longitudinal Study of Adolescent Health. RESULTS: Primary analysis indicated that childhood maltreatment was a significant risk factor for later behaviors that violate rules and the rights of others (p < .05), there were no main effects of MAOA genotype, and MAOA genotype was not a significant moderator of the relationship between maltreatment and antisocial behaviors in our white sample. Post hoc analyses identified a similar pattern of results among our black sample in which maltreatment was not a significant predictor of antisocial behavior. Post hoc analyses also revealed a main effect of MAOA genotype on having a disposition toward violence in both samples and for violent convictions among our black sample. None of these post hoc findings, however, survived correction for multiple testing (p > .05). Power analyses indicated that these results were not due to insufficient statistical power. CONCLUSIONS: We could not confirm the hypothesis that MAOA genotype moderates the relationship between childhood maltreatment and adult antisocial behaviors.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/10.1016/j.biopsych.2013.03.028
ID  - ref1
ER  -