TY  - JOUR
PY  - 2006//
TI  - ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American college students
JO  - Journal of studies on alcohol
A1  - Luczak, Susan E.
A1  - Shea, Shoshana H.
A1  - Hsueh, Annie C.
A1  - Chang, Jenss
A1  - Carr, Lucinda G.
A1  - Wall, Tamara L.
SP  - 349
EP  - 353
VL  - 67
IS  - 3
N2  - OBJECTIVE: A recent report found the heritability estimate for alcohol-induced blackouts was 53%. The present study was designed to determine whether possession of two specific genetic variations, an aldehyde dehydrogenase ALDH2*2 allele and an alcohol dehydrogenase ADHIB*2 allele, were associated with lower rates of lifetime blackouts. METHOD: Asian American college students (N=403) of Chinese and Korean descent were genotyped at the ALDH2 and ADHIB loci and assessed for lifetime alcohol-induced blackouts and the maximum number of drinks ever consumed in a 24-hour period. RESULTS: Participants who had an ALDH2*2 allele had approximately one third the risk of having a lifetime blackout of participants without this allele. Rates of experiencing a lifetime blackout did not significantly differ by ADHIB*2 status. Possessing an ALDH2*2 allele was associated with decreased risk of lifetime blackouts even after controlling for maximum number of drinks ever consumed in a 24-hour period and ethnicity. CONCLUSIONS: These findings suggest the protective effects of possessing an ALDH2*2 allele include a lowered risk of experiencing alcohol-induced blackouts.<p /> <p>Language: en</p>
LA  - en
SN  - 0096-882X
UR  - http://dx.doi.org/
ID  - ref1
ER  -