TY  - JOUR
PY  - 2004//
TI  - Acamprosate in alcohol dependence: a randomized controlled efficacy study in a standard clinical setting
JO  - Journal of studies on alcohol
A1  - Baltieri, Danilo Antonio
A1  - de Andrade, Arthur Guerra
SP  - 136
EP  - 139
VL  - 65
IS  - 1
N2  - OBJECTIVE: This study was undertaken to evaluate the efficacy and safety of acamprosate in the treatment of alcohol dependence. METHOD: The investigation was a double-blind, placebo-controlled, 24-week study carried out at the University of São Paulo, Brazil. The sample comprised 75 patients, 18-60 years of age, with an International Classification of Diseases (ICD-10) diagnosis of alcohol dependence. After a 1-week detoxification period the patients were randomly divided into two groups: the first received acamprosate (1.998 mg/day) and the second received placebo. After the first 12 weeks, the patients continued follow-up for a similar length of time without medication. The main outcome measures were relapse rates, side effects and time to first relapse. RESULTS: On an intention-to-treat basis, the Kaplan-Meier survival curve showed an advantage in relapse rates for acamprosate over placebo (log-rank test, p = .02), and acamprosate was well tolerated. CONCLUSIONS: Acamprosate seems to be an effective treatment for alcohol dependence in a Brazilian population.<p /> <p>Language: en</p>
LA  - en
SN  - 0096-882X
UR  - http://dx.doi.org/
ID  - ref1
ER  -