TY  - JOUR
PY  - 2002//
TI  - The effects of low Km aldehyde dehydrogenase (ALDH2) phenotype on drinking behavior in Japanese university students
JO  - Journal of studies on alcohol
A1  - Sobue, Ikuko
A1  - Takeshita, Tatsuya
A1  - Maruyama, Soichiro
A1  - Morimoto, Kanehisa
SP  - 527
EP  - 530
VL  - 63
IS  - 5
N2  - OBJECTIVE: The present study investigated the relationship between a history of a flushing reaction and drinking behavior in Japanese university students, adjusting for the effects of alcohol-related psychosocial factors including academic year, school division, club membership and housing situation. METHOD: In 1995, 419 men and 321 women at Kyoto University were enrolled in a study using informed consent. Subjects were classified as nonflushers or flushers by using a self-reported measure, the ALST (Alcohol Sensitivity Screening Test). Alcohol drinking behavior during the last year, including drinking frequency, alcohol intake per occasion and problem drinking behavior, was investigated. RESULTS: Compared with male flushers, male nonflushers showed a 1.8 times higher frequency of drinking with family members (p < .01) and drank significantly larger amounts of alcohol with family members (p < .05). Male nonflushers drank significantly larger amounts of alcohol with friends than did male flushers (p < .0001) and showed significantly heavier mean alcohol consumption per month than male flushers did (p < .001). Compared with male flushers, male nonflushers showed a 1.7 times higher rate of high-problem drinking (p < .01). In contrast, none of these drinking behaviors differed between female nonflushers and female flushers. CONCLUSIONS: Even after adjusting for aspects of alcohol-related psychosocial factors, flushing reactions among Japanese university students were significantly related to drinking behavior in men but not in women.<p /> <p>Language: en</p>
LA  - en
SN  - 0096-882X
UR  - http://dx.doi.org/
ID  - ref1
ER  -