TY - JOUR PY - 1991// TI - Close linkage of esterase-D to unipolar depression and alcoholism is ruled out in eight pedigrees JO - Journal of studies on alcohol A1 - Wesner, R. B. A1 - Tanna, V. L. A1 - Palmer, P. J. A1 - Thompson, R. J. A1 - Crowe, R. R. A1 - Winokur, G. SP - 609 EP - 612 VL - 52 IS - 6 N2 - Unipolar depression and alcoholism were tested for genetic linkage to esterase-D at 13q14.1. Tight linkage to esterase-D was ruled out for three phenotypes using three models of penetrance: (1) unipolar depression and alcoholism taken together as affected, (2) unipolar depression alone as affected with alcoholism considered unaffected and (3) alcoholism alone as affected with unipolar depression considered unaffected. This study does not support an earlier finding of possible linkage between the esterase-D locus at 13q14.1 and alcoholism.
Language: en
LA - en SN - 0096-882X UR - http://dx.doi.org/ ID - ref1 ER -