TY  - JOUR
PY  - 1985//
TI  - Is there acute tolerance to alcohol at steady state?
JO  - Journal of studies on alcohol
A1  - Kaplan, H. L.
A1  - Sellers, E. M.
A1  - Hamilton, C.
A1  - Naranjo, C. A.
A1  - Dorian, P.
SP  - 253
EP  - 256
VL  - 46
IS  - 3
N2  - Although acute tolerance to the psychomotor impairment caused by alcohol has been documented in single-dose studies, the pharmacodynamic effects of continued alcohol administration in humans have not been well studied. Six nonalcoholic men received alcohol to achieve and maintain breath alcohol levels of 80-100 mg/dl for 6 hr. The men suffered an initial impairment in word recall but improved over the next 6 hr. Measures of standing steadiness and manual tracking did not show evidence of the development of tolerance. This lack of tolerance was reflected in subjects' self-assessments of sedation and intoxication.<p /> <p>Language: en</p>
LA  - en
SN  - 0096-882X
UR  - http://dx.doi.org/
ID  - ref1
ER  -