TY  - JOUR
PY  - 2013//
TI  - Symptomatic white matter changes in mild traumatic brain injury resemble pathologic features of early Alzheimer dementia
JO  - Radiology
A1  - Fakhran, Saeed
A1  - Yaeger, Karl
A1  - Alhilali, Lea
SP  - 249
EP  - 257
VL  - 269
IS  - 1
N2  - Purpose: To evaluate white matter integrity in patients with mild traumatic brain injury (TBI) who did not have morphologic abnormalities at conventional magnetic resonance (MR) imaging with diffusion-tensor imaging to determine any relationship between patterns of white matter injury and severity of postconcussion symptoms.    Materials and Methods:The institutional review board approved this study, with waiver of informed consent. Diffusion-tensor images from 64 consecutive patients with mild TBI obtained with conventional MR imaging were evaluated retrospectively. Fractional anisotropy (FA) maps were generated as a measure of white matter integrity. All patients underwent a neurocognitive evaluation. Correlations between skeletonized FA values in white matter, total concussion symptom score, and findings of sleep and wake disturbances were analyzed with regression analysis that used tract-based spatial statistics.    Results: Total concussion symptom scores varied from 2 to 97 (mean ± standard deviation, 32.7 ± 24.4), with 34 patients demonstrating sleep and wake disturbances. Tract-based spatial statistics showed a significant correlation between high total concussion symptom score and reduced FA at the gray matter-white matter junction (P < .05), most prominently in the auditory cortex (P < .05). FA in the parahippocampal gyri was significantly decreased in patients with sleep and wake disturbances relative to patients without such disturbances (0.26 and 0.37, respectively; P < .05).    Conclusion: The distribution of white matter abnormalities in patients with symptomatic mild TBI is strikingly similar to the distribution of pathologic abnormalities in patients with early Alzheimer dementia, a finding that may help direct research strategies.© RSNA, 2013.<p />  <p>Language: en</p>
LA  - en
SN  - 0033-8419
UR  - http://dx.doi.org/10.1148/radiol.13122343
ID  - ref1
ER  -